Chromosomes: Keeping Centromeric Chromatin Tidy through S Phase
نویسندگان
چکیده
منابع مشابه
A novel cis-acting centromeric DNA element affects S. pombe centromeric chromatin structure at a distance
The chromatin structure of the central core region of Schizosaccharomyces pombe centromeric DNA is unusual. This distinctive chromatin structure is associated only with central core sequences in a functional context and is modulated by a novel cis-acting DNA element (centromere enhancer) within the functionally critical K centromeric repeat, which is found in multiple copies in all three S. pom...
متن کاملSequences specify centromeric chromatin
n page 765, Ohzeki et al. present evidence for sequence specificity in assembling chromatin at mammalian centromeres. The sequence requirements imply that construction of centromeric chromatin is more than an epigenetic process. O Centromeric chromatin assembles at AT-rich repeats called ␣ satellite sequences, or alphoids. Type I alphoids contain boxes for the binding of CENP-B, one of several ...
متن کاملCentromeric chromatin gets loaded
Centromeric nucleosomes contain a histone H3 variant called centromere protein A (CENP-A) that is required for kinetochore assembly and chromosome segregation. Two new studies, Jansen et al. (see p. 795 of this issue) and Maddox et al. (see p. 757 of this issue), address when CENP-A is deposited at centromeres during the cell division cycle and identify an evolutionally conserved protein requir...
متن کاملCentromeric Chromatin: Histone deviants
Highly variant histones are targeted to specialized chromatin domains, such as the centromere where they have an essential role in the segregation of sister chromatids at mitosis.
متن کاملCentromeric chromatin in fission yeast.
A fundamental requirement for life is the ability of cells to divide properly and to pass on to their daughters a full complement of genetic material. The centromere of the chromosome is essential for this process, as it provides the DNA sequences on which the kinetochore (the proteinaceous structure that links centromeric DNA to the spindle microtubules) assembles to allow segregation of the c...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Current Biology
سال: 2019
ISSN: 0960-9822
DOI: 10.1016/j.cub.2018.11.044